2024 NFL Week 6 Preview: Key Matchups, Betting Odds, and Predictions

As we enter Week 6 of the 2024 NFL season, teams are beginning to solidify their identities, making each game crucial for both standings and betting enthusiasts. With marquee matchups across the league, let’s dive into the top games and odds for this week.

Top Matchups:

  1. Buffalo Bills (-2.5) vs. New York Jets Monday Night Football sees the Bills as 2.5-point favorites on the road against the Jets. This AFC East clash will feature Josh Allen going up against a revamped Jets team. While Buffalo aims to bounce back from a shaky start, New York’s defense is key in keeping the game close. Current spread: Bills -2.5, O/U: 43.5​(FOX Sports)​(RotoWire).
  2. San Francisco 49ers (-3) vs. Seattle Seahawks Thursday Night Football brings a classic NFC West rivalry, with the 49ers heading to Seattle as 3-point favorites. San Francisco will look to dominate the line of scrimmage, while the Seahawks rely on their home-field advantage to stymie the 49ers’ offense. This game could swing either way depending on turnover battles. Current spread: 49ers -3, O/U: 46.5​(RotoWire)​(The Lines).
  3. Detroit Lions (-2.5) vs. Dallas Cowboys In a pivotal NFC showdown, the Lions visit the Cowboys as 2.5-point favorites. The Lions are fresh off a bye and will be looking to stay atop the NFC North, while the Cowboys will try to assert themselves at home. With both defenses playing at a high level, this game is expected to be tightly contested. Current spread: Lions -2.5, O/U: 51.5​(Sports Betting Predictions)​(RotoWire).
  4. Cleveland Browns (+9) vs. Philadelphia Eagles The Eagles are favored by 9 points as they take on a Browns team that has struggled to find consistency. Philadelphia’s offense could get a boost if key receivers return from injury. Meanwhile, Cleveland’s defense will need to step up to cover the spread. Current spread: Eagles -9, O/U: 43.5​(Sports Betting Predictions)​(Covers.com).

Other Key Games:

  • Tampa Bay Buccaneers (+2.5) vs. New Orleans Saints
    • The Saints are slight home favorites in this divisional battle. Both teams will be looking to rebound after tough losses. Current spread: Saints -2.5, O/U: 45.5​(The Lines).
  • Los Angeles Chargers (-3) vs. Denver Broncos
    • The Chargers are looking to snap their losing streak as they head to Mile High as 3-point favorites. Denver, coming off a strong defensive performance, could keep this game close. Current spread: Chargers -3, O/U: 35.5​(Sports Betting Predictions).

Betting Insights:

Week 6 provides many opportunities for close games and intriguing betting lines. Detroit vs. Dallas and 49ers vs. Seahawks are must-watch games where late line movements could offer added value. Keep an eye on injuries and team news before locking in bets, particularly for the Eagles vs. Browns and Commanders vs. Ravens​(RotoWire)​(The Lines).


Featured Games

Home TeamAway TeamDateFavoriteSpreadOdds
SEATTLE SEAHAWKSSAN FRANCISCO 49ERS2024-10-11SAN FRANCISCO 49ERS-3.51.91
CHICAGO BEARSJACKSONVILLE JAGUARS2024-10-13CHICAGO BEARS-2.01.91
GREEN BAY PACKERSARIZONA CARDINALS2024-10-13GREEN BAY PACKERS-5.01.89
BALTIMORE RAVENSWASHINGTON COMMANDERS2024-10-13BALTIMORE RAVENS-6.51.93
PHILADELPHIA EAGLESCLEVELAND BROWNS2024-10-13PHILADELPHIA EAGLES-9.01.89
NEW ENGLAND PATRIOTSHOUSTON TEXANS2024-10-13HOUSTON TEXANS-7.01.93
TENNESSEE TITANSINDIANAPOLIS COLTS2024-10-13TENNESSEE TITANS-2.51.89
NEW ORLEANS SAINTSTAMPA BAY BUCCANEERS2024-10-13TAMPA BAY BUCCANEERS-3.51.95
DENVER BRONCOSLOS ANGELES CHARGERS2024-10-13LOS ANGELES CHARGERS-3.01.95
LAS VEGAS RAIDERSPITTSBURGH STEELERS2024-10-13PITTSBURGH STEELERS-3.01.89
CAROLINA PANTHERSATLANTA FALCONS2024-10-13ATLANTA FALCONS-6.01.91
DALLAS COWBOYSDETROIT LIONS2024-10-13DETROIT LIONS-3.01.89
NEW YORK GIANTSCINCINNATI BENGALS2024-10-14CINCINNATI BENGALS-3.51.98
NEW YORK JETSBUFFALO BILLS2024-10-15BUFFALO BILLS-2.51.93